*LIQUIDSCAN®

ISOLATE RARE CELLS AND EXOSOMES – CTCs, TROPHOBLASTS, EVs

BioFluidica has created LiquidScan® as a unique fully automated system for isolating and enriching rare cells and exosomes from liquid biopsy samples. The system uses a microfluidic chip surfaced with antibodies targeting biomarkers of interest, creating the future of liquid biopsy.

LIQUIDSCAN® WORKFLOW

1

LOAD

Flow whole blood over capture chip

2

CAPTURE

Capture rare cells or exo-somesp

3

WASH

Wash to eliminate background

4

ELUTE

Elute rare cells or exosomes

5

ANALYZE

1 The BioFluidica LiquidScan hardware & software modules are integrated into the Hamilton Microlab STAR and STARlet liquid handling robot.

2 The LiquidScan Software controls loading the sample(s) onto the microfluidic chips, washing to remove background cells and cleavage and elution of captured cells or EVs from the chip.

3 The software creates a secure-loop system, two-pipette tips per chip, which dispense and aspirate simultaneously enabling relatively large volumes of liquid biopsy sample to be passed through the chip.

THE *LIQUIDSCAN SYSTEM

  • LiquidScan Microfluidic Chip Processing Module
  • LiquidScan Reagent Kit
    (with LiquidScan Microfluidic Chips surfaced with antibodies)
  • LiquidScan Software
  • LiquidScan installs on a Hamilton Microlab STARlet or STAR liquid handling robot
    (Contact us regarding pre-owned, new or adding LiquidScan to one you already have)

*For Research Use Only.

LIQUIDSCAN REAGENT KITS

  • Reagent plate with contents ready to process 4 or 8 microfluidic chips
  • Microfluidic chips (4 or 8):
    • Antibody-surfaced sinusoidal chips for rare-cell capture or,
    • Antibody-surfaced pillar chips for exosome subpopulation capture
  • Sample tubes (8)
  • Waste tubes or re-process sample tubes (8)

PILLAR & SINUSOIDAL CHIPS

  • Microfluidic chip surface is tunable to isolate biomarkers of interest. Established for isolation of Exosomes in plasma and Rare cells in whole blood.
  • Release of isolated target analytes can be optimized for downstream applications.
  • Enzymatic release for evaluation of EV or Rare Cell surface markers or lyse on chip for nucleic acid or protein investigation.